Document Detail

Selectivity of proteinuria during pregnancy assessed by different methods.
MedLine Citation:
PMID:  1005055     Owner:  NLM     Status:  MEDLINE    
Relative protein clearance measurements have gone a long way toward characterizing the nature of pregnancy proteinuria but have failed to distinguish between preeclampsia and primary renal disease. The prognostic significance of different degrees of selectivity has been a source of disagreement in past studies. The polymer clearance studies reported here, using tracer doses of labeled PVP, have demonstrated two forms of proteinuria: a benign form due to a vasoconstrictor effect where fetal outlook is good ("vasoactive"), and a form associated with intravascular coagulation which indicates worse fetal prognosis ("membranous"). Underlying chronic renal damage of minor degree is identifiable with PVP clearance. Concurrent measurements of protein clearance, using smaller-sized proteins than is customary, gave hope for future development of meaningful clinical tests.
S M Wood; D Burnett; J Studd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Perspectives in nephrology and hypertension     Volume:  5     ISSN:  0092-2900     ISO Abbreviation:  Perspect Nephrol Hypertens     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0402144     Medline TA:  Perspect Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
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MeSH Terms
Hypertension / physiopathology,  urine*
Infant Mortality
Infant, Newborn
Infant, Small for Gestational Age
Kidney Glomerulus / physiopathology
Povidone / urine
Pre-Eclampsia / physiopathology,  urine*
Pregnancy Complications / physiopathology,  urine*
Pregnancy Complications, Cardiovascular / physiopathology,  urine
Proteins / physiology
Proteinuria* / physiopathology
Puerperal Disorders / physiopathology,  urine
Reg. No./Substance:
0/Proteins; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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