Document Detail

Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins.
MedLine Citation:
PMID:  8094261     Owner:  NLM     Status:  MEDLINE    
Various heterotrimeric guanine nucleotide-binding proteins have been identified on the basis of the individual subtypes of their alpha subunits. The beta gamma complexes, composed of beta and gamma subunits, remain tightly associated under physiological conditions and have been assumed to constitute a common pool shared among various guanosine triphosphate (GTP)-binding (G) protein heterotrimers. Particular alpha and beta subunit subtypes participate in the signal transduction processes between somatostatin or muscarinic receptors and the voltage-sensitive L-type calcium channel in rat pituitary GH3 cells. Among gamma subunits the gamma 3 subtype was found to be required for coupling of the somatostatin receptor to voltage-sensitive calcium channels, whereas the gamma 4 subtype was found to be required for coupling of the muscarinic receptor to those channels.
C Kleuss; H Scherübl; J Hescheler; G Schultz; B Wittig
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  259     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-4     Citation Subset:  IM    
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.
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MeSH Terms
Base Sequence
Calcium / metabolism
Calcium Channels / physiology*
Carbachol / pharmacology
GTP-Binding Proteins / genetics,  metabolism*
Macromolecular Substances
Molecular Sequence Data
Oligonucleotides, Antisense / pharmacology
Pituitary Neoplasms
RNA, Messenger / genetics,  isolation & purification,  metabolism
Signal Transduction / drug effects,  physiology*
Somatostatin / pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Calcium Channels; 0/Macromolecular Substances; 0/Oligodeoxyribonucleotides; 0/Oligonucleotides, Antisense; 0/RNA, Messenger; 51-83-2/Carbachol; 51110-01-1/Somatostatin; 7440-70-2/Calcium; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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