Document Detail

Selective use of diagnostic tests inpatients with syncope of unknown cause.
MedLine Citation:
PMID:  12628723     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to prospectively assess the diagnostic yielding of a protocol in which electrophysiologic studies (EPS), tilt-table tests (TTTs), and loop recorder implantation are selectively used. BACKGROUND: The optimal strategy in the diagnosis of patients with syncope of unknown cause has not been defined. METHODS: A total of 184 consecutive patients with syncope of unknown cause were classified into two groups. Group A consisted of 72 patients fulfilling any of the following criteria: 1) presence of structural heart disease or family history of sudden death; 2) abnormal electrocardiogram; 3) significant non-symptomatic arrhythmia on Holter monitoring; and 4) paroxysmal palpitations immediately before or after syncope. These patients initially underwent an EPS and, if this study was negative, TTT. In the remaining 112 patients (group B), TTT was performed. RESULTS: The EPS was positive in 32 patients (44%) in group A. The TTT was positive in 80 patients (71%) in group B. An additional patient had carotid sinus hypersensitivity. In patients of group A with a negative EPS, the TTT was positive in 23 (57%). A loop recorder was implanted in 15 patients from group A with negative conventional testing, and diagnostic activation was obtained in seven patients. Overall, a positive diagnosis was achieved in 143 patients (78%). CONCLUSIONS: In patients with syncope of unknown cause, selective use of EPS or TTT leads to a positive diagnosis in >70% of the cases. An implantable loop recorder can be useful in non-diagnosed cases.
Roberto Garcia-Civera; Ricardo Ruiz-Granell; Salvador Morell-Cabedo; Rafael Sanjuan-Mañez; Francisco Perez-Alcala; Eva Plancha; Alejandro Navarro; Segismundo Botella; Angel LLacer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  41     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-90     Citation Subset:  AIM; IM    
Department of Cardiology, Hospital Clinico Universitario, Valencia, Spain.
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MeSH Terms
Cohort Studies
Diagnosis, Differential
Diagnostic Tests, Routine
Electrocardiography, Ambulatory / methods
Electrodes, Implanted
Electrophysiology / methods*
Heart Diseases / diagnosis*
Medical History Taking
Middle Aged
Prospective Studies
Sensitivity and Specificity
Statistics, Nonparametric
Syncope / diagnosis*,  etiology
Syncope, Vasovagal / diagnosis,  etiology
Tilt-Table Test
Comment In:
J Am Coll Cardiol. 2003 Mar 5;41(5):791-4   [PMID:  12628724 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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