| Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study. | |
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MedLine Citation:
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PMID: 22357259 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The passage from shore to marine life of juvenile penguins represents a major energetic challenge to fuel intense and prolonged demands for thermoregulation and locomotion. Some functional changes developed at this crucial step were investigated by comparing pre-fledging king penguins with sea-acclimatized (SA) juveniles (Aptenodytes patagonicus). Transcriptomic analysis of pectoralis muscle biopsies revealed that most genes encoding proteins involved in lipid transport or catabolism were upregulated, while genes involved in carbohydrate metabolism were mostly downregulated in SA birds. Determination of muscle enzymatic activities showed no changes in enzymes involved in the glycolytic pathway, but increased 3-hydroxyacyl-CoA dehydrogenase, an enzyme of the β-oxidation pathway. The respiratory rates of isolated muscle mitochondria were much higher with a substrate arising from lipid metabolism (palmitoyl-l-carnitine) in SA juveniles than in terrestrial controls, while no difference emerged with a substrate arising from carbohydrate metabolism (pyruvate). In vivo, perfusion of a lipid emulsion induced a fourfold larger thermogenic effect in SA than in control juveniles. The present integrative study shows that fuel selection towards lipid oxidation characterizes penguin acclimatization to marine life. Such acclimatization may involve thyroid hormones through their nuclear beta receptor and nuclear coactivators. |
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Authors:
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Loic Teulier; Cyril Dégletagne; Benjamin Rey; Jérémy Tornos; Céline Keime; Marc de Dinechin; Mireille Raccurt; Jean-Louis Rouanet; Damien Roussel; Claude Duchamp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-22 |
Journal Detail:
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Title: Proceedings. Biological sciences / The Royal Society Volume: - ISSN: 1471-2954 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101245157 Medline TA: Proc Biol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Université de Lyon, UMR5023 Ecologie des Hydrosystèmes Naturels et Anthropisés, , Université Lyon 1, ENTPE, CNRS, 6 rue Raphaël Dubois, 69622 Villeurbanne, France, Université de Lyon, UMR 5558 Laboratoire de Biométrie et Biologie Évolutive, , Université Lyon 1, CNRS, 69622 Villeurbanne, France, Institute of Genetics, Molecular and Cellular Biology, , 1 rue Laurent Fries, 67404 Illkirch, France, UMR 5175 Centre d'Ecologie Fonctionnelle et Evolutive, , CNRS, 1919 Route de Mende, 34293 Montpellier, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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