Document Detail

Selective transport of staphylococcal enterotoxin A through in vitro generated human M cells.
MedLine Citation:
PMID:  17905625     Owner:  NLM     Status:  MEDLINE    
Staphylococcal enterotoxins are responsible for food poisoning and toxic shock syndrome due to their superantigen activity on T cells. Although their activity necessarily involves passage through the intestinal epithelium, little is known about this critical step. In the present study, we compared the in vitro transport of staphylococcal enterotoxin A through human intestinal absorptive and M cells. We found that the transport of the toxin through M cells was polarized and temperature-sensitive, in contrast with the less efficient transport of the toxin by absorptive cells. These data suggest the involvement of M cells in the intestinal absorption of staphylococcal enterotoxins.
Marc Maresca; Eliane Dumay; Jacques Fantini; Bertrand Caporiccio
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Publication Detail:
Type:  Journal Article     Date:  2007-07-21
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  9     ISSN:  1286-4579     ISO Abbreviation:  Microbes Infect.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1507-10     Citation Subset:  IM    
Laboratoire des Interactions Moléculaires et Systèmes Membranaires (IMSM), Université Paul Cézanne, Faculté des Sciences et Techniques de Saint-Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.
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MeSH Terms
B-Lymphocytes / metabolism*
Biological Transport*
Caco-2 Cells
Cell Line
Cell Polarity
Coculture Techniques
Enterotoxins / metabolism*
Epithelial Cells / metabolism*
Intestines / cytology,  metabolism*
Reg. No./Substance:
0/Enterotoxins; 37337-57-8/enterotoxin A, Staphylococcal

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