Document Detail

Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation.
MedLine Citation:
PMID:  21034861     Owner:  NLM     Status:  MEDLINE    
FROM THE CLINICAL EDITOR: The toxicity of zinc oxide to bacteria was related to the generation of reactive oxygen species and to the induction of apoptosis. Interestingly, these effects were differentially greater in human myeloblastic leukemia cells (HL60) than normal peripheral blood mononuclear cells.
Mariappan Premanathan; Krishnamoorthy Karthikeyan; Kadarkaraithangam Jeyasubramanian; Govindasamy Manivannan
Publication Detail:
Type:  Journal Article     Date:  2010-10-27
Journal Detail:
Title:  Nanomedicine : nanotechnology, biology, and medicine     Volume:  7     ISSN:  1549-9642     ISO Abbreviation:  Nanomedicine     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-22     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  101233142     Medline TA:  Nanomedicine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi, Tamil Nadu, India.
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MeSH Terms
Anti-Bacterial Agents / toxicity*
Antineoplastic Agents / toxicity*
Apoptosis / drug effects
DNA Fragmentation
Gram-Positive Bacteria / drug effects*,  physiology
HL-60 Cells
Leukocytes, Mononuclear
Lipid Peroxidation / drug effects
Metal Nanoparticles / toxicity*
Neoplasms / metabolism,  physiopathology*
Zinc Oxide / toxicity*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 1314-13-2/Zinc Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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