| Selective termination of aneuploidy utilizing rapid fluorescence in situ hybridization detection techniques. | |
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MedLine Citation:
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PMID: 11771188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twin pregnancy following assisted reproductive technology with a euploid fetus and a coexisting aneuploid co-twin constitutes a conflicting situation; therefore, it is important for the genetic constitution of each co-twin to be diagnosed accurately and promptly for parental genetic counseling and subsequent aggressive management. A 35-year-old woman, gravida 1, with a 2-year history of infertility, presented bilateral fallopian tubal obstruction at her infertility workups, for which she received in vitro fertilization; subsequently she conceived a twin pregnancy. She underwent genetic amniocentesis at 16 weeks' gestation, as indicated by an advanced maternal age. Presented with the diagnosis of twin pregnancy with discordancy for trisomy 21, a rapid fluorescence in situ hybridization (FISH) technique for aneuploidy mapping was applied for subsequent abdominal selective fetal reduction. The FISH technique facilitates the rapid analysis of uncultured amniocytes. Normal (disomic) and trisomic samples can be distinguished clearly and rapidly for subsequent selective fetocide. The FISH technique is an important tool in prenatal diagnosis and clinical applications. |
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Authors:
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Y Y Lee; C I Chen; H C Chang; C H Liu; M S Lee |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Chang Gung medical journal Volume: 24 ISSN: 2072-0939 ISO Abbreviation: Chang Gung Med J Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-12-28 Completed Date: 2002-01-10 Revised Date: 2008-12-16 |
Medline Journal Info:
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Nlm Unique ID: 101088034 Medline TA: Chang Gung Med J Country: China (Republic: 1949- ) |
Other Details:
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Languages: eng Pagination: 646-50 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chung Shan Medical & Dental College Hospital, 23, Section 1, Taichung-Kang Road, Taichung 403, Taiwan, R.O.C. cshlee356@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aneuploidy* Diseases in Twins* Female Humans In Situ Hybridization, Fluorescence* Pregnancy Pregnancy Reduction, Multifetal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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