Document Detail

Selective techniques of apheresis in polyneuropathy associated with monoclonal gammopathy of undetermined significance.
MedLine Citation:
PMID:  8191874     Owner:  NLM     Status:  MEDLINE    
Three cases affected by peripheral neuropathy associated to monoclonal gammopathy of undetermined significance (MGUS) were treated by using selective apheretic techniques, chosen on the basis of the serological characteristics of the gammopathy. Double filtration plasmapheresis was used in the first two cases, respectively affected by gammopathy of IgM type, kappa chains, and IgG type, lambda chains; protein A immunoadsorption in Case 3 with IgG type, lambda chains. Apheretic sessions were performed for three-four months, in association with low-dose immunosuppressive therapy. Clear and stable improvement of the neuropathy over 12-month follow-up period was observed both from a clinical and electrophysiological point of view. It is concluded that in peripheral neuropathy associated with MGUS selective techniques of apheresis can prove useful both in obtaining positive results and in avoiding the collateral effect of the original plasma exchange.
G Siciliano; L Moriconi; G Gianni; E Richieri; M G Vignocchi; B Rossi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  89     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-17     Completed Date:  1994-06-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Institute of Neurology Clinic, University of Pisa, Italy.
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MeSH Terms
Blood Component Removal / methods*
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Immunoglobulin M / immunology
Immunosorbent Techniques
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / complications*,  immunology,  therapy*
Neural Pathways / immunology
Paraproteinemias / complications*,  immunology*,  therapy
Peripheral Nervous System Diseases / complications*,  immunology,  therapy*
Plasmapheresis / methods*
Treatment Outcome
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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