Document Detail


Selective surgical management of correctable hypergastrinemia.
MedLine Citation:
PMID:  2573956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty patients with surgically correctable hypergastrinemia were treated between 1960 and 1988. Provocative testing was used when available to select appropriate operations. Sources of hypergastrinemia included antral G cell hyperplasia (AGCH) (17), pancreatic gastrinomas (14), duodenal gastrinomas (11), multiple gastrinomas in patients with type I multiple endocrine neoplasia (MEN I) (five), lymph node gastrinomas (four), and the source not found in nine patients. Eugastrinemia was achieved by resection in 17 of 17 patients with AGCH, nine of 11 patients with duodenal gastrinomas, three of four patients with lymph node gastrinomas, zero of 14 patients with pancreatic gastrinomas, zero of five patients with MEN I, and zero of nine patients in whom the source was not found. Hepatic metastases developed in 11 patients with pancreatic gastrinomas, two patients with MEN I, one patient with duodenal gastrinomas, and one patient with lymph node gastrinomas. One patient in whom the source of the hypergastrinemia was not found developed hepatic metastases, and seven required total gastrectomy. This experience suggests the following: (1) that patients with AGCH, duodenal gastrinomas, or lymph node gastrinomas can usually be rendered eugastrinemic by resection; (2) that patients with pancreatic gastrinomas, whether sporadic or familial (MEN I), are rarely cured by resection and frequently develop hepatic metastases; and (3) that patients in whom the source of the hypergastrinemia is not identified and removed frequently require total gastrectomy, but antroduodenectomy should be considered because it may uncover an occult duodenal microneurogastrinoma or may correct AGCH.
Authors:
R Delcore; A S Hermreck; S R Friesen
Related Documents :
7362006 - Postcholecystectomy syndrome and its association with ampullary stenosis.
17520216 - Prevalence of autoimmune pancreatitis in japan from a nationwide survey in 2002.
1739176 - Internal pancreatic fistula.
12604906 - Coagulative disorders in human acute pancreatitis: role for the d-dimer.
24259826 - Characteristics of postural sway during quiet standing before and after the occurrence ...
7362006 - Postcholecystectomy syndrome and its association with ampullary stenosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  106     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-08     Completed Date:  1990-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1094-100; discussion 1100-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Kansas School of Medicine, Mo.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Duodenal Neoplasms / blood,  surgery*
Eating
Female
Follow-Up Studies
Gastrinoma / blood,  surgery*
Gastrins / blood*,  secretion
Humans
Hyperplasia
Male
Middle Aged
Multiple Endocrine Neoplasia / blood,  surgery*
Pancreatic Neoplasms / blood,  surgery*
Prognosis
Secretin / diagnostic use
Stomach / pathology,  surgery
Stomach Neoplasms / blood,  surgery*
Tumor Markers, Biological / blood*
Chemical
Reg. No./Substance:
0/Gastrins; 0/Tumor Markers, Biological; 1393-25-5/Secretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The surgical treatment of gastrinoma in MEN I syndrome patients.
Next Document:  Management of islet cell tumors in patients with multiple endocrine neoplasia: a prospective study.