Document Detail

Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans.
MedLine Citation:
PMID:  2295086     Owner:  NLM     Status:  MEDLINE    
In C. elegans males, laterally located V cells generate a simple pattern of anterior alae (cuticular ridges) and posterior rays (mating sensilla). We have found that this pattern is generated, at least in part, by the selective interruption of cell-cell interactions. In anterior V cells, lineages leading to the production of alae are induced by cell interactions. These cell interactions are inhibited in specific posterior V cells by the activity of the gene pal-1, which allows these cells to generate rays instead of alae. The activities of cell signals and pal-1 appear to influence V cell fates by determining the state of a developmental switch that involves two homeotic genes, lin-22 and mab-5.
D A Waring; C Kenyon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  60     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  IM    
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
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MeSH Terms
Caenorhabditis / genetics,  growth & development,  physiology*
Cell Communication*
Cell Division

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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