Document Detail

Selective serotonin reuptake inhibitors in the context of hepatitis C infection: reexamining the risks of bleeding.
MedLine Citation:
PMID:  17685737     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are used to treat interferon-associated depression in patients receiving hepatitis C virus therapy. Prior studies have cautioned against the combined use of SSRIs and interferon due to increased risk of hemorrhage. Given the morbidity of depression and its impact on interferon compliance, we sought to reexamine the data. METHOD: In a retrospective analysis of our database of hepatitis C virus patients, a consecutive series of 303 patients (receiving treatment between January 2001 and January 2005) were evaluated for any evidence of bleeding. On the basis of our standard practice of care, patients were treated prophylactically with antidepressants for 3 to 4 weeks before beginning combination therapy with interferon and ribavirin. Patients were evaluated every 4 weeks during antiviral treatment with physical examinations and complete blood cell counts with differentials and platelets. RESULTS: The overall rate of bleeding in our study was 0.3%, representing a single case of hemophilia. CONCLUSIONS: The bleeding risk of SSRIs is lower than previously reported.
Kari A Martin; Lois E Krahn; Vijayan Balan; Marianne J Rosati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  68     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-09-28     Revised Date:  2008-06-16    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1024-6     Citation Subset:  IM    
Department of Psychiatry and Psychology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
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MeSH Terms
Antiviral Agents / adverse effects*,  therapeutic use
Depressive Disorder / chemically induced,  drug therapy*
Drug Interactions
Hemorrhage / chemically induced*
Hepatitis C / drug therapy*
Interferons / adverse effects*,  therapeutic use
Middle Aged
Retrospective Studies
Ribavirin / therapeutic use
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Antiviral Agents; 0/Serotonin Uptake Inhibitors; 36791-04-5/Ribavirin; 9008-11-1/Interferons
Comment In:
J Clin Psychiatry. 2008 Apr;69(4):679-80   [PMID:  18507491 ]

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