Document Detail


Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice.
MedLine Citation:
PMID:  18155696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hot flushes are one of the most frequent symptoms in menopausal women. Selective serotonin reuptake inhibitors (SSRIs) are considered to be first-line therapy for the treatment of hot flushes in women for whom hormone therapy is contraindicated. Recently, we have proposed forced exercise-induced flushing of tail skin in ovariectomized mice as a new experimental model of temperature dysregulation in menopausal hot flushes. In the present study, to validate this animal model as a tool for testing potential compounds for the treatment of menopausal hot flushes, we examined the effects of two SSRIs (fluvoxamine and paroxetine) on forced exercise-induced flushing of tail skin in ovariectomized mice, and compared it with that of estradiol replacement (1 mg/kg/week for 3 weeks, i.m.). Treatment with fluvoxamine (20 mg/kg, i.p.) or paroxetine (10 mg/kg, i.p.) completely inhibited forced exercise-induced flushing of tail skin in ovariectomized mice, and the effect of each was comparable to that of estradiol replacement. It is believed that the present findings provide the first experimental evidence to support the anti-flushing effects of SSRIs, such as fluvoxamine and paroxetine, in a clinical setting. An animal model with forced exercise probably serves as a useful experimental tool for evaluating the effects of different agents on hot flushes.
Authors:
Munehiko Ikeda; Takashi Egawa; Atsushi Yamauchi; Yoshio Sohda; Ayako Koga; Kohji Tominaga; Hideki Shuto; Yasufumi Kataoka
Related Documents :
15456776 - Control of exercise-stimulated muscle glucose uptake by glut4 is dependent on glucose p...
24202776 - An analysis of carbon dioxide transport in arterial and venous blood of the rainbow tro...
23590606 - Relationship between ventilation and predicted arterial co(2) pressure during recovery ...
18784336 - Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle.
2881396 - Organisation of collagen fibrils in tendon: changes induced by an anabolic steroid. i. ...
15456776 - Control of exercise-stimulated muscle glucose uptake by glut4 is dependent on glucose p...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-28
Journal Detail:
Title:  European journal of pharmacology     Volume:  579     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Estradiol / pharmacology
Estrogens / pharmacology
Female
Fluvoxamine / administration & dosage,  pharmacology*
Hot Flashes / drug therapy*,  etiology
Humans
Menopause / physiology
Mice
Mice, Inbred ICR
Models, Animal*
Ovariectomy
Paroxetine / administration & dosage,  pharmacology*
Physical Conditioning, Animal / physiology
Serotonin Uptake Inhibitors / administration & dosage,  pharmacology*
Skin Temperature / drug effects
Tail
Chemical
Reg. No./Substance:
0/Estrogens; 0/Serotonin Uptake Inhibitors; 50-28-2/Estradiol; 54739-18-3/Fluvoxamine; 61869-08-7/Paroxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Behavioral effects of amphetamine in streptozotocin-treated rats.
Next Document:  Functional role of beta 1 integrin-mediated signalling in the human hair follicle.