Document Detail

Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice.
MedLine Citation:
PMID:  18155696     Owner:  NLM     Status:  MEDLINE    
Hot flushes are one of the most frequent symptoms in menopausal women. Selective serotonin reuptake inhibitors (SSRIs) are considered to be first-line therapy for the treatment of hot flushes in women for whom hormone therapy is contraindicated. Recently, we have proposed forced exercise-induced flushing of tail skin in ovariectomized mice as a new experimental model of temperature dysregulation in menopausal hot flushes. In the present study, to validate this animal model as a tool for testing potential compounds for the treatment of menopausal hot flushes, we examined the effects of two SSRIs (fluvoxamine and paroxetine) on forced exercise-induced flushing of tail skin in ovariectomized mice, and compared it with that of estradiol replacement (1 mg/kg/week for 3 weeks, i.m.). Treatment with fluvoxamine (20 mg/kg, i.p.) or paroxetine (10 mg/kg, i.p.) completely inhibited forced exercise-induced flushing of tail skin in ovariectomized mice, and the effect of each was comparable to that of estradiol replacement. It is believed that the present findings provide the first experimental evidence to support the anti-flushing effects of SSRIs, such as fluvoxamine and paroxetine, in a clinical setting. An animal model with forced exercise probably serves as a useful experimental tool for evaluating the effects of different agents on hot flushes.
Munehiko Ikeda; Takashi Egawa; Atsushi Yamauchi; Yoshio Sohda; Ayako Koga; Kohji Tominaga; Hideki Shuto; Yasufumi Kataoka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-28
Journal Detail:
Title:  European journal of pharmacology     Volume:  579     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Estradiol / pharmacology
Estrogens / pharmacology
Fluvoxamine / administration & dosage,  pharmacology*
Hot Flashes / drug therapy*,  etiology
Menopause / physiology
Mice, Inbred ICR
Models, Animal*
Paroxetine / administration & dosage,  pharmacology*
Physical Conditioning, Animal / physiology
Serotonin Uptake Inhibitors / administration & dosage,  pharmacology*
Skin Temperature / drug effects
Reg. No./Substance:
0/Estrogens; 0/Serotonin Uptake Inhibitors; 50-28-2/Estradiol; 54739-18-3/Fluvoxamine; 61869-08-7/Paroxetine

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