Document Detail

Selective serotonin reuptake inhibitor induced neonatal abstinence syndrome.
MedLine Citation:
PMID:  18982836     Owner:  NLM     Status:  MEDLINE    
Depression is common in women of childbearing age and especially during pregnancy and the postpartum period. Selective serotonin reuptake inhibitors (SSRIs) are increasingly being used to treat depression prior to and throughout pregnancy. Up to 30% of the newborn infants exposed to SSRIs may present with clinical signs during the first days after birth. Neonatal abstinence syndrome (NAS) describes this clinical syndrome resulting from prior prolonged exposure to SSRI induced by cessation of the drug. NAS includes a wide spectrum from mild to severe nonspecific symptoms which were categorized into four groups of effects: central nervous system (depression followed by excitation), gastrointestinal, autonomic and respiratory. A protocol for observation of SSRI-exposed newborns is presented including an objective method (Finnegan score) to monitor onset, progression and improvement of NAS symptoms.
Gil Klinger; Paul Merlob
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Israel journal of psychiatry and related sciences     Volume:  45     ISSN:  0333-7308     ISO Abbreviation:  Isr J Psychiatry Relat Sci     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-05     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8108287     Medline TA:  Isr J Psychiatry Relat Sci     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
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MeSH Terms
Infant, Newborn
Neonatal Abstinence Syndrome / etiology*
Prenatal Exposure Delayed Effects / epidemiology,  etiology
Risk Factors
Serotonin Uptake Inhibitors / adverse effects*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors

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