Document Detail

Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake.
MedLine Citation:
PMID:  17189653     Owner:  NLM     Status:  MEDLINE    
Ghrelin (Ghr) is an appetite stimulating hormone that is produced peripherally, by the stomach, and centrally as well. Previous investigations show that Ghr increases food intake and memory retention in rats, and that extra-hypothalamic structures, such as the hippocampus, participate in these effects. In the present work we analyzed the effect on food intake and memory retention induced by Ghr after serotonin (5-HT) availability modification at the serotoninergic synapses. Animals only treated with a selective serotonin reuptake inhibitor (SSRI), fluoxetine (FLU) 5 mg/kg or clomipramine (CLO) 2.5 and 5 mg/kg, showed a significant reduction in both food intake and memory retention. On the contrary, Ghr administration induces a significant increase in food intake and a dose-dependent increase in short and long term memory retention. When the animals were treated with FLU prior to Ghr injection, the food intake induced, as well as the expression of short and long term memory retention, was decreased. In conclusion, evidence presented in this paper suggests that the effects of Ghr on both feeding and memory retention in extra-hypothalamic structures such as the hippocampus, could depend on the availability of 5-HT.
Valeria P Carlini; Romina C Gaydou; Helgi B Schiöth; Susana R de Barioglio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-26
Journal Detail:
Title:  Regulatory peptides     Volume:  140     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Departamento de Farmacología, Facultad de Ciencias Químicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, Universidad Nacional de Córdoba, 5016 Córdoba, Argentina.
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MeSH Terms
Brain / drug effects
Clomipramine / pharmacology
Dose-Response Relationship, Drug
Eating / drug effects*
Fluoxetine / pharmacology*
Hippocampus / drug effects
Memory / drug effects*
Models, Biological
Peptide Hormones / pharmacology*
Rats, Wistar
Serotonin Uptake Inhibitors / pharmacology*
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine; 54910-89-3/Fluoxetine

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