Document Detail

Selective serotonin reuptake inhibitor discontinuation syndrome: a review.
MedLine Citation:
PMID:  12008858     Owner:  NLM     Status:  MEDLINE    
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed in the treatment of depression and anxiety, as well as obsessive-compulsive, eating, and impulse-control disorders. Paralleling their widespread use has been an increase in adverse-effect reports not noted during short-term efficacy studies. Significant among these adverse effects is SSRI discontinuation syndrome, which follows the interruption of extended treatment or a reduction in drug dosage and entails somatic and psychological symptoms. These self-limiting symptoms resolve on reintroduction of the drug and cannot be explained as a remanifestation of the original disorder. To facilitate proper diagnosis and avoid unnecessary therapeutic or diagnostic interventions, all physicians who prescribe SSRIs should become familiar with these symptoms. The most appropriate approach to therapy for discontinuation syndrome involves educating patients and reassuring them that this is a reversible condition, reinstating the original SSRI, and further slowing the rate of tapering.
Lut Tamam; Nurgul Ozpoyraz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in therapy     Volume:  19     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-05-14     Completed Date:  2002-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  T    
Cukurova University Faculty of Medicine, Department of Psychiatry, Adana, Turkey.
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MeSH Terms
Antidepressive Agents, Second-Generation / adverse effects*
Serotonin Uptake Inhibitors / adverse effects*
Substance Withdrawal Syndrome / diagnosis*
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Serotonin Uptake Inhibitors

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