Document Detail


Selective sensing of metalloproteins from nonselective binding using a fluorogenic amphiphilic polymer.
MedLine Citation:
PMID:  16910656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonconjugated fluorogenic amphiphilic polymers containing an anthracene chromophore exhibit fluorescence quenching in the presence of metalloproteins, although the binding of the polymer to proteins is not selective. The reason for this difference is that the possible conformational changes that protein binding could bring about on a polymer do not affect the fluorescence properties of a pendent chromophore in nonconjugated polymers. This is in contrast to the nonspecific binding and response found with conjugated polymers to proteins.
Authors:
Britto S Sandanaraj; Robert Demont; Sivakumar V Aathimanikandan; Elamprakash N Savariar; S Thayumanavan
Related Documents :
16439176 - Alpha-l-iduronidase transport in neurites.
15728576 - Location and mobility of twin arginine translocase subunits in the escherichia coli pla...
24101586 - Lysosomal network proteins as potential novel csf biomarkers for alzheimer's disease.
23921886 - Protein array-based profiling of csf identifies rbpj as an autoantigen in multiple scle...
17905836 - The intrinsically disordered tc-1 interacts with chibby via regions with high helical p...
15253416 - Quantification in proteomics through stable isotope coding: a review.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  128     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2007-08-15     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10686-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Fluorescent Dyes / chemistry*
Metalloproteins / chemistry*
Molecular Structure
Polymers / chemistry*
Spectrometry, Fluorescence
Surface-Active Agents / chemistry*
Grant Support
ID/Acronym/Agency:
GM-65255/GM/NIGMS NIH HHS; R01 GM065255/GM/NIGMS NIH HHS; R01 GM065255-03/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 0/Metalloproteins; 0/Polymers; 0/Surface-Active Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stochastic detection of enantiomers.
Next Document:  Water-soluble through-bond energy transfer cassettes for intracellular imaging.