Document Detail


Selective regional perfusion of the bilateral external carotid arteries with pegylated liposomal doxorubicin and melphalan to treat metastatic malignant melanoma of the scalp.
MedLine Citation:
PMID:  20659118     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We present the case of a 79-year-old patient with extensive metastatic malignant melanoma (MM) of the scalp. Cutaneous MM of the head and neck often presents a therapeutic challenge. Radical surgical procedures and conventional chemotherapy are often unfeasible and contraindicated because of the difficult anatomy, the extent of the tumour process, and systemic toxicity. In our patient, selective intra-arterial perfusion with pegylated liposomal doxorubicin (PLD) and melphalan was performed after catheterization of both bilateral external carotid arteries with an arterial port system. PLD 4.5 mg/m(2) and melphalan (1.35 mg/m(2) , followed by 2.7 mg/m(2) after reaching tolerance) were given as short-term infusions at two-weekly intervals into the right and left external carotid arteries, respectively. After eight applications with tolerable side-effects, no MM cells were detected; however, infiltrates of lymphocytes and melanophages were seen. This case suggests that intra-arterial chemotherapy may be a useful treatment for metastatic melanoma of the scalp.
Authors:
D Göppner; S R Quist; I Franke; J Ulrich; U Drecoll; T Bürger; H P M Gollnick; B Bonnekoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  36     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  270-2     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s). Journal compilation © 2010 British Association of Dermatologists.
Affiliation:
Dermatology and Venerology Clinic, Otto-von-Guericke University, Magdeburg, Germany Dermatology Clinic, Dorothea Christiane Erxleben Hospital, Quedlingburg, Germany Department of Dermatology, University Charité Berlin, Berlin, Germany Department of Visceral Surgery, Magdeburg, Germany.
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