| Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. | |
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MedLine Citation:
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PMID: 11756989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactivation of human beta-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human beta-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P=.001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/10(6) peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill patients. These findings contribute to the less-defined epidemiology of HHV-6A infection. |
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Authors:
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Raymund R Razonable; Cara Fanning; Robert A Brown; Mark J Espy; Antonio Rivero; Jennie Wilson; Walter Kremers; Thomas F Smith; Carlos V Paya |
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Publication Detail:
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Type: Journal Article Date: 2001-12-14 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 185 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2001-12-28 Completed Date: 2002-01-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 110-3 Citation Subset: AIM; IM |
Affiliation:
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Division of Infectious Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Betaherpesvirinae / genetics, growth & development Cardiovascular Diseases / complications Communicable Diseases / complications Critical Illness DNA, Viral / blood Female Genetic Variation Herpesvirus 6, Human / genetics*, growth & development* Humans Male Middle Aged Nervous System Diseases / complications Roseolovirus Infections / complications*, genetics, immunology* Virus Activation / immunology* Wounds and Injuries / complications |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2002 Jun 15;185(12):1843; author reply 1843-4
[PMID:
12085338
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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