Document Detail


Selective production of staplabin and SMTPs in cultures of Stachybotrys microspora fed with precursor amines.
MedLine Citation:
PMID:  11827039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Staplabin and SMTPs, a family of triprenyl phenol metabolites of Stachybotrys microspora, enhance fibrinolysis by modulating plasminogen conformation to increase its susceptibility to activation by plasminogen activators. We found that the production of these metabolites were markedly elevated by feeding the microbial culture with an amino acid or an amino alcohol that is a partial molecular constituent of the compound. Thus, the addition of 5-aminovaleric acid, 2-aminoethanol, Ser, Phe, Leu, Trp, Orn and Lys at 100 mg/ml resulted in 7- to 45-fold increases in the production of staplabin, SMTP-1, -3, -4, -5, -6, -7 and -8, respectively. Although the feeding at day 0 to 3 of culture supported the selective production, the supplementation after 5 days had little or no effect. When non-constituent amino acids were supplemented to cultures, production of hitherto uncharacterized congeners was observed.
Authors:
W Hu; R Narasaki; S Ohyama; K Hasumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  54     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-02-05     Completed Date:  2002-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  962-6     Citation Subset:  IM    
Affiliation:
Department of Applied Biological Science, Tokyo Noko University, Fuchu, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry,  metabolism*
Amino Alcohols / chemistry,  metabolism*
Benzopyrans / metabolism*
Chromatography, High Pressure Liquid
Plasminogen Activators / metabolism*
Pyrrolidinones / metabolism*
Stachybotrys / chemistry,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Amino Alcohols; 0/Benzopyrans; 0/Pyrrolidinones; 0/staplabin; EC 3.4.21.-/Plasminogen Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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