Document Detail


Selective processing of food words during insulin-induced hypoglycemia in healthy humans.
MedLine Citation:
PMID:  14726998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Hypoglycemia leads to undernutrition of the brain. Favoring selective processing of food stimuli would be an adaptive cognitive strategy. However, hypoglycemia is known to impair several aspects of cognitive function, and it is unknown whether selective cognitive processing of food stimuli occurs during insulin-induced hypoglycemia. METHODS: In a single-blind repeated measures design, healthy young adults (n=12, six female, mean age 28 years; mean body mass index 22.5 kg/m(2)) performed a standard Stroop word-color test, as well as a variant with food words designed to detect selective processing of food cues. Two sessions were scheduled with a 4-week interval. In each session, a hyperinsulinemic clamp method produced a normoglycemic (plasma glucose: 4.7 mmol/l) period, followed on 1 day by a hypoglycemic (2.7 mmol/l) testing period, and on the other day a second normoglycemic testing period (counterbalanced order). RESULTS: Color naming verbal reaction time (RT) increased during hypoglycemia (P<0.0001). The extent of the Stroop cognitive interference was independent of plasma glucose level. The key finding is that RT for food words increased more than for non-food control words (P<0.004), and this effect was not predicted by hunger ratings. CONCLUSIONS: Our data provide new evidence that during hypoglycemia, attention is directed selectively to food-relevant stimuli. The results are discussed in terms of adaptation.
Authors:
Stuart Brody; Ulrich Keller; Lukas Degen; Daniel J Cox; Hartmut Schächinger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-15
Journal Detail:
Title:  Psychopharmacology     Volume:  173     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Affiliation:
Division of Psychosomatic Medicine, BIM, University Hospital Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Adult
Attention / drug effects,  physiology
Blood Glucose / analysis
Cognition / physiology*
Emotions / physiology
Female
Food Preferences / psychology*
Glucose Clamp Technique / methods
Humans
Hypoglycemia / blood,  chemically induced,  physiopathology*,  psychology
Insulin
Male
Neuropsychological Tests
Photic Stimulation
Reaction Time / physiology
Single-Blind Method
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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