| Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity. | |
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MedLine Citation:
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PMID: 19631720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholinergic projections originating in the basal forebrain (BF) play important roles in the heterosynaptic facilitation of synaptic strength in various sensory cortices, including the primary visual cortex (V1). Here, using urethane-anesthetized rats, we find that pairing burst stimulation of the BF with single pulse stimulation of the lateral geniculate nucleus (LGN) does not consistently increase field postsynaptic potentials (fPSPs) in V1 elicited by ipsilateral LGN stimulation. However, longer latency fPSPs recorded in V1 in response to stimulation of the contralateral LGN, reflecting crossed, polysynaptic inputs, show significant potentiation when paired with preceding BF stimulation. This synaptic enhancement requires relatively short time intervals between paired BF burst and LGN pulse stimulation (40 ms) and is abolished by systemic or local V1 muscarinic receptor blockade (scopolamine), while systemic nicotinic receptor blockade (mecamylamine) is ineffective. Together, these data provide evidence for a differential capacity for cholinergic/muscarinic-dependent plasticity induction among different signals in V1, with inputs reaching V1 from the contralateral LGN exhibiting potentiation in the face of stable strength in ipsilateral LGN-V1 projections. This preferential readiness for potentiation in crossed fiber systems could serve to amplify binocular responses in V1 elicited by synchronized excitation of ipsi- and contralateral LGN neurons. |
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Authors:
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Peter J Gagolewicz; Hans C Dringenberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-23 |
Journal Detail:
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Title: Neuroscience letters Volume: 463 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-17 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 130-4 Citation Subset: IM |
Affiliation:
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Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Animals Electric Stimulation Geniculate Bodies / physiology* Male Mecamylamine / pharmacology Muscarinic Antagonists / pharmacology Neuronal Plasticity Nicotinic Antagonists / pharmacology Prosencephalon / physiology* Rats Rats, Long-Evans Scopolamine / pharmacology Synapses / physiology Synaptic Potentials Vision, Binocular / physiology* Visual Cortex / physiology |
| Chemical | |
Reg. No./Substance:
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0/Muscarinic Antagonists; 0/Nicotinic Antagonists; 51-34-3/Scopolamine; 51-84-3/Acetylcholine; 60-40-2/Mecamylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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