| Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid. | |
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MedLine Citation:
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PMID: 8633675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to determine the feasibility of selective photosensitization of vulvar condylomas by use of tropical application of 5-aminolevulinic acid. STUDY DESIGN: In vivo fluorescence was assessed and biopsy specimens of condylomas were taken for fluorescence microscopy in 24 patients at different times after application of 2.5% 5-aminolevulinic acid ointment or 20% 5-aminolevulinic acid cream. RESULTS: Both in vivo fluorescence imaging and fluorescence microscopy showed selective fluorescence of condylomas of the labia minora and vestibule only within short time intervals, because fluorescence of poorly keratinized normal epithelium was induced by both 5-aminolevulinic acid formulations. In non-hair-bearing skin, lesional fluorescence remained highly selective. Fluorescence microscopy showed that 90 minutes after drug application peak selectivity in epithelial lesional fluorescence was significantly higher with 2.5% 5-aminolevulinic acid ointment (4.5 +/- 0.9) than it was with 20% cream (2.1 +/- 0.2). CONCLUSION: Selective fluorescence of vulvar condyloma acuminatum can be induced by nonselective topical 5-aminolevulinic acid application. Studies evaluating selective photodynamic destruction of condylomas are justified. |
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Authors:
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M K Fehr; C F Chapman; T Krasieva; B J Tromberg; J L McCullough; M W Berns; Y Tadir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 174 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-07-03 Completed Date: 1996-07-03 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 951-7 Citation Subset: AIM; IM |
Affiliation:
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Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aminolevulinic Acid / administration & dosage, pharmacokinetics*, therapeutic use Condylomata Acuminata / drug therapy*, metabolism Feasibility Studies Female Humans Microscopy, Fluorescence Ointments Photochemotherapy Photosensitizing Agents / administration & dosage, pharmacology*, therapeutic use Tissue Distribution Vulvar Diseases / drug therapy*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01CA32248/CA/NCI NIH HHS; R29GM50958/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 0/Photosensitizing Agents; 106-60-5/Aminolevulinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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