Document Detail


Selective partial IgM deficiency: functional assessment of T and B lymphocytes in vitro.
MedLine Citation:
PMID:  2872228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven patients with selective IgM deficiency (SIgMD) were studied for cell surface immunoglobulin (SmIg), T-cell subpopulations, and immunoglobulin (Ig) synthesis in vitro by peripheral blood lymphocytes (PBL). Serum IgM levels were less than 25 mg/dl, while IgA, IgG, and IgD were within normal levels. The patients had respiratory or urinary tract infections and two were diagnosed as having systemic lupus erythematosus (SLE). T/B-cell ratios in PBL were within normal ranges. Percentage ratios of B cells bearing SmIg were normal in five patients and decreased in two; however, normal values were seen after 7 days of culture in the presence of PWM. OKT4/OKT8 ratios decreased in five of seven patients, in whom two were due to a decrease in OKT4 and two to an increase in OKT8 cells. One showed a decrease in OKT4 and an increase in OKT8. Analysis of lymphocyte function for Ig synthesis in vitro, using a coculture of counterpart T and B cells from healthy individuals and patients with SIgMD, revealed that the increased function of IgM isospecific suppressor T cells (Ts) was responsible for the IgM deficiency in all seven patients.
Authors:
T Inoue; Y Okumura; M Shirama; H Ishibashi; S Kashiwagi; H Okubo
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  6     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
B-Lymphocytes / classification,  immunology*
Dysgammaglobulinemia / immunology*
Female
Humans
Immunoglobulin M / deficiency*
Immunoglobulins / biosynthesis
Male
Middle Aged
Pokeweed Mitogens / pharmacology
Receptors, Antigen, B-Cell / analysis
T-Lymphocytes / classification,  immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulin M; 0/Immunoglobulins; 0/Pokeweed Mitogens; 0/Receptors, Antigen, B-Cell

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