| Selective and pan-blockade agents in the anti-angiogenic treatment of proliferative diabetic retinopathy: a literature summary. | |
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MedLine Citation:
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PMID: 20648074 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Diabetes mellitus is a major health concern in the modern world. Several sight-threatening ocular conditions are included in the array of health problems associated with this disease. Understandably, 2 of the more sight-threatening problems, proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME), have received a great deal of attention in recent years. Pivotal studies, such as the Early Treatment Diabetic Retinopathy Study and the Diabetic Retinopathy Study, have established laser photocoagulation as the accepted treatment modality. The last decade has seen a surge in clinical data supporting the use of pharmacologic therapy in place of the often damaging laser therapy. Supporting data are based on the establishment of vascular endothelial growth factor (VEGF) as a key facilitator of disease progression in diabetic retinopathy. We will discuss the advantages and disadvantages of both selective and pan-blockade anti-VEGF agents available today in an effort to help guide physicians wishing to use these agents to treat PDR and DME. |
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Authors:
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Gian Paolo Giuliari; D Aaron Guel; Maria Angelica Cortez; Rafael T Cortez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Volume: 45 ISSN: 0008-4182 ISO Abbreviation: Can. J. Ophthalmol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045312 Medline TA: Can J Ophthalmol Country: Canada |
Other Details:
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Languages: eng Pagination: 501-8 Citation Subset: IM |
Affiliation:
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Massachusetts Eye and Research Surgery Institution, Cambridge, Mass., USA. gpgiuliari@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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