| Selective mobilization of fatty acids from adipose tissue triacylglycerols. | |
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MedLine Citation:
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PMID: 12689620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose tissue triacylglycerols represent the main storage of a wide spectrum of fatty acids differing by molecular structure. The release of individual fatty acids from adipose tissue is selective according to carbon chain length and unsaturation degree in vitro and in vivo in animal studies and also in humans. The mechanism of selective fatty acid mobilization from white fat cells is not known. Lipolysis is widely reported to work at a lipid-water interface where only small amounts of substrate are available. A preferential hydrolysis of a small triacylglycerol fraction enriched in certain triacylglycerol molecular species at the lipid-water interface and enzymological properties of hormone-sensitive lipase could explain the selective mobilization of fatty acids from fat cells. This selectivity could affect the individual fatty acid supply to tissues. |
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Authors:
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Thierry Raclot |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in lipid research Volume: 42 ISSN: 0163-7827 ISO Abbreviation: Prog. Lipid Res. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-04-11 Completed Date: 2003-08-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7900832 Medline TA: Prog Lipid Res Country: England |
Other Details:
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Languages: eng Pagination: 257-88 Citation Subset: IM |
Affiliation:
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Centre d'Ecologie et de Physiologie Energétiques, CNRS UPR 9010, associé à l'Université Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France. thierry.raclot@c-strasbourg.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Fatty Acids / metabolism* Fatty Acids, Nonesterified / metabolism Fatty Acids, Omega-3 / metabolism Humans Hydrolysis Lipase / metabolism Lipid Mobilization Nutritional Physiological Phenomena* Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Triglycerides; EC 3.1.1.3/Lipase |
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