Document Detail


Selective mobilization of fatty acids from adipose tissue triacylglycerols.
MedLine Citation:
PMID:  12689620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adipose tissue triacylglycerols represent the main storage of a wide spectrum of fatty acids differing by molecular structure. The release of individual fatty acids from adipose tissue is selective according to carbon chain length and unsaturation degree in vitro and in vivo in animal studies and also in humans. The mechanism of selective fatty acid mobilization from white fat cells is not known. Lipolysis is widely reported to work at a lipid-water interface where only small amounts of substrate are available. A preferential hydrolysis of a small triacylglycerol fraction enriched in certain triacylglycerol molecular species at the lipid-water interface and enzymological properties of hormone-sensitive lipase could explain the selective mobilization of fatty acids from fat cells. This selectivity could affect the individual fatty acid supply to tissues.
Authors:
Thierry Raclot
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in lipid research     Volume:  42     ISSN:  0163-7827     ISO Abbreviation:  Prog. Lipid Res.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-08-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7900832     Medline TA:  Prog Lipid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-88     Citation Subset:  IM    
Affiliation:
Centre d'Ecologie et de Physiologie Energétiques, CNRS UPR 9010, associé à l'Université Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France. thierry.raclot@c-strasbourg.fr
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Fatty Acids / metabolism*
Fatty Acids, Nonesterified / metabolism
Fatty Acids, Omega-3 / metabolism
Humans
Hydrolysis
Lipase / metabolism
Lipid Mobilization
Nutritional Physiological Phenomena*
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Triglycerides; EC 3.1.1.3/Lipase

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