| Selective left-lobe atrophy by nodularin treatment accompanied by reduced protein phosphatase 1/2A and increased peroxisome proliferation in rat liver. | |
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MedLine Citation:
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PMID: 11149417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of nodularin on selective atrophy of left lobes in the liver was investigated in F344 rats. Nodularin was injected for 10 weeks from the third week of initiation with saline or N-nitrosodiethylamine (DEN), grouped as S/N and D/N, respectively. Nodularin significantly decreased weights of left (LL) and caudate (CL) lobes but increased right (RL) and middle (ML) lobes in S/N rats. Activity of protein phosphatases [types 1 (PPI) and 2A (PP2A)] was more severely reduced in S/N than D/N rats; moreover, in LL compared with RL of S/N rats, activity was significantly inhibited by nodularin treatment from week 4, which corresponded to 2 weeks after nodularin injection. However, nodularin significantly induced peroxisomal palmitoyl-CoA oxidase and cytochrome P-450 4A1 expression in S/N compared with D/N rats. An effect of nodularin on apoptosis was evident since expression of Bcl-Xs was clearly induced in LL of S/N rats as opposed to various inductions of Bcl-XL. However, Bcl-XL in RL was persistently induced, with undetectable Bcl-Xs expression. These results demonstrate biochemical evidence of selective atrophy of LL by inhibition of PP1 and PP2A activity, increase of peroxisomal enzymes and induction of Bcl-Xs expression, in contrast to proliferation of RL in rats treated with nodularin alone. However, nodularin endowed DEN-altered hepatocytes with regenerating power and concomitant restoration of phosphatase activity as well as persistent expression of Bcl-XL in D/N rats. |
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Authors:
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I K Lim; T J Park; S C Park; G Yoon; C S Kwak; M S Le; K Y Song; Y K Choi; B H Hyun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 91 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-08 Completed Date: 2001-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 32-40 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, South Korea. iklim@madang.ajou.ac.kr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents Animals Apoptosis Atrophy / chemically induced Blotting, Western Carcinogens Diethylnitrosamine Liver / drug effects, pathology* Liver Neoplasms / chemically induced, metabolism Male Organ Size / drug effects Oxidoreductases / metabolism Peptides, Cyclic* Peroxisomes / metabolism* Phosphoprotein Phosphatases / metabolism* Protein Phosphatase 1 Proto-Oncogene Proteins c-bcl-2 / metabolism Rats Rats, Inbred F344 Time Factors bcl-X Protein |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Bcl2l1 protein, rat; 0/Carcinogens; 0/Peptides, Cyclic; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-X Protein; 118399-22-7/nodularin; 55-18-5/Diethylnitrosamine; EC 1.-/Oxidoreductases; EC 1.3.3.-/palmitoyl CoA oxidase; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/Protein Phosphatase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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