| Selective laser sintering of porous tissue engineering scaffolds from poly(L: -lactide)/carbonated hydroxyapatite nanocomposite microspheres. | |
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MedLine Citation:
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PMID: 17619975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L: -lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had a size range of 5-30 microm, suitable for the SLS process. Microstructural analyses revealed that the CHAp nanospheres were embedded throughout the PLLA microsphere, forming a nanocomposite structure. A custom-made miniature sintering platform was installed in a commercial Sinterstation((R)) 2000 SLS machine. This platform allowed the use of small quantities of biomaterials for TE scaffold production. The effects of laser power; scan spacing and part bed temperature were investigated and optimized. Finally, porous scaffolds were successfully fabricated from the PLLA microspheres and PLLA/CHAp nanocomposite microspheres. In particular, the PLLA/CHAp nanocomposite microspheres appeared to be promising for porous bone TE scaffold production using the SLS technique. |
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Authors:
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Wen You Zhou; Siu Hang Lee; Min Wang; Wai Lam Cheung; Wing Yuk Ip |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-10 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 19 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2009-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 2535-40 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, The University of Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Substitutes
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chemistry* Hot Temperature Hydroxyapatites / chemistry*, radiation effects Lasers* Materials Testing Microspheres Nanostructures / chemistry*, radiation effects, ultrastructure* Polyesters / chemistry* Porosity Surface Properties Tissue Engineering / methods* |
| Chemical | |
Reg. No./Substance:
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0/Bone Substitutes; 0/Hydroxyapatites; 0/Polyesters; 26969-66-4/poly(lactide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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