Document Detail


Selective inhibition of the uptake by bloodstream form Trypanosoma brucei brucei of serum lipoprotein-associated phospholipid and cholesteryl ester.
MedLine Citation:
PMID:  2169029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To further define how culture-adapted bloodstream form Trypanosoma brucei brucei take up lipoprotein-associated 3H-labelled lipids, external effectors were included in the incubation mixtures and assessed for their ability to influence lipid uptake. Serum molecules of 30-85 kDa, which could be replaced by albumin, selectively inhibited the uptake by culture-adapted T. b. brucei of lipoprotein-associated phospholipid and enhanced the uptake of lipoprotein-associated cholesteryl ester and cholesteryl ether. In contrast, both bile acids and protein synthesis inhibitors exerted a greater inhibitory effect on the uptake by T. b. brucei of lipoprotein-associated cholesteryl ester and cholesteryl ether than on the uptake of lipoprotein-associated phospholipid. Investigations into the mode of action of the inhibitors suggested that T. b. brucei induces release of lipoprotein-associated phospholipid prior to its uptake and that albumin binds free phospholipid, thus reducing its uptake by the T. b. brucei. The bile acids reduced parasite cholesteryl ester uptake by acting directly on the trypanosomes and did not either influence parasite protein synthesis or disrupt lipoprotein particles at the concentrations used.
Authors:
V Vandeweerd; S J Black
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  41     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-12     Completed Date:  1990-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  197-206     Citation Subset:  IM    
Affiliation:
International Laboratory for Research on Animal Diseases, Nairobi, Kenya.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / pharmacology
Cholesterol Esters / metabolism*
Cycloheximide / pharmacology
Lipid Metabolism
Lipoproteins, HDL / metabolism*
Lipoproteins, LDL / metabolism*
Lithocholic Acid / metabolism
Phosphatidylcholines / metabolism
Phospholipases / antagonists & inhibitors
Phospholipids / metabolism*
Phosphoric Monoester Hydrolases / antagonists & inhibitors
Protease Inhibitors / pharmacology
Trypanosoma brucei brucei / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholesterol Esters; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Phosphatidylcholines; 0/Phospholipids; 0/Protease Inhibitors; 434-13-9/Lithocholic Acid; 66-81-9/Cycloheximide; EC 3.1.-/Phospholipases; EC 3.1.3.-/Phosphoric Monoester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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