Document Detail


Selective inhibition of proteins regulating CDK/cyclin complexes: strategy against cancer--a review.
MedLine Citation:
PMID:  20560705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer prevention is a global priority, but history indicates that the journey towards achieving the goal is difficult. Various cyclin dependent kinase complexes (CDKs/cyclins) operate as major cell signaling components in all stages of cell cycle. CDK/cyclin protein complexes, regulating the cell cycle, are conserved during evolution. In cancer cells, cell division is uncontrolled and CDKs/cyclins become 'check-points' or targets. Keeping this in view the proteins cyclin C, cyclin D2, CDKN1C, and Growth Arrest and DNA Damage (GADD45alpha) which play a major role in regulating CDK/cyclin complexes and operate in the initial stages of cell cycle (G(0) phase-S phase), have been identified as promising targets. Targeting critical regulators of cell-cycle signaling components by applying modern computational techniques is projected to be a potential tool for future cancer research.
Authors:
P Sarita Rajender; D Ramasree; K Bhargavi; M Vasavi; V Uma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of receptor and signal transduction research     Volume:  30     ISSN:  1532-4281     ISO Abbreviation:  J. Recept. Signal Transduct. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509432     Medline TA:  J Recept Signal Transduct Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  206-13     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Nizam College, Basheerbagh, Hyderabad, Andhra Pradesh, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / therapeutic use
Cyclin-Dependent Kinases / metabolism*
Cyclins / metabolism*
Humans
Multiprotein Complexes / metabolism*
Neoplasm Proteins / metabolism
Neoplasms / drug therapy,  metabolism*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cyclins; 0/Multiprotein Complexes; 0/Neoplasm Proteins; EC 2.7.11.22/Cyclin-Dependent Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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