| Selective inhibition of proteins regulating CDK/cyclin complexes: strategy against cancer--a review. | |
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MedLine Citation:
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PMID: 20560705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer prevention is a global priority, but history indicates that the journey towards achieving the goal is difficult. Various cyclin dependent kinase complexes (CDKs/cyclins) operate as major cell signaling components in all stages of cell cycle. CDK/cyclin protein complexes, regulating the cell cycle, are conserved during evolution. In cancer cells, cell division is uncontrolled and CDKs/cyclins become 'check-points' or targets. Keeping this in view the proteins cyclin C, cyclin D2, CDKN1C, and Growth Arrest and DNA Damage (GADD45alpha) which play a major role in regulating CDK/cyclin complexes and operate in the initial stages of cell cycle (G(0) phase-S phase), have been identified as promising targets. Targeting critical regulators of cell-cycle signaling components by applying modern computational techniques is projected to be a potential tool for future cancer research. |
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Authors:
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P Sarita Rajender; D Ramasree; K Bhargavi; M Vasavi; V Uma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of receptor and signal transduction research Volume: 30 ISSN: 1532-4281 ISO Abbreviation: J. Recept. Signal Transduct. Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509432 Medline TA: J Recept Signal Transduct Res Country: England |
Other Details:
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Languages: eng Pagination: 206-13 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Nizam College, Basheerbagh, Hyderabad, Andhra Pradesh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use Cyclin-Dependent Kinases / metabolism* Cyclins / metabolism* Humans Multiprotein Complexes / metabolism* Neoplasm Proteins / metabolism Neoplasms / drug therapy, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cyclins; 0/Multiprotein Complexes; 0/Neoplasm Proteins; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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