Document Detail


Selective inhibition of herpes simplex virus glycoprotein synthesis by a benz-amidinohydrazone derivative.
MedLine Citation:
PMID:  6255895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1H-benz[f]indene-1.3(2H)dione-bis-amidinohydrazone (benzhydrazone) inhibited incorporation of 14C-glucosamine, 14C-fucose and 14C-mannose into glycoproteins of HEp-2 cells infected with various strains of herpes simplex virus 1 (HSV-1) and impaired RNA and protein synthesis to a low extent. These biochemical effects are very similar to those induced by glycosylation inhibitors such as tunicamycin, D-glucosamine and 2-deoxy-D-glucose. In contrast to these inhibitors, benzhydrazone reduced HSV glycoprotein synthesis selectively since it did not significantly modify i) the saccharide uptake into glycoproteins of uninfected and of Sindbis virus-infected cells, ii) viral growth and cell fusion in paramyxovirus-infected cells, two activities which depend on viral glycoprotein synthesis. Benzhydrazone had only minor effects on the overall metabolism of uninfected cells, since it did not alter cell growth rate, and amino acid, uridine, and hexose incorporations were about 80% those of untreated cells.
Authors:
G Campadelli-Fiume; P Sinibaldi-Vallebona; V Cavrini; A Mannini-Palenzona
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of virology     Volume:  66     ISSN:  0304-8608     ISO Abbreviation:  Arch. Virol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  179-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cricetinae
Cytopathogenic Effect, Viral / drug effects
Glycoproteins / biosynthesis*
Hydrazones / pharmacology*
Measles virus / growth & development
Paramyxoviridae / growth & development
RNA, Viral / biosynthesis
Simplexvirus / drug effects,  growth & development,  metabolism*
Viral Proteins / biosynthesis*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Hydrazones; 0/RNA, Viral; 0/Viral Proteins; 76788-93-7/benzhydrazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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