| Selective inhibition of glial cell metabolism in vivo by fluorocitrate. | |
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MedLine Citation:
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PMID: 1515906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fluorocitrate on glial and neuronal amino acid metabolism was studied. One nmol of fluorocitrate administered intrastriatally in the rat caused a 95% reduction of glutamine formation from [14C]acetate, a substrate which enters the glial cells selectively. The metabolism of [14C]glucose which enters neurons, was unaffected by fluorocitrate treatment except for the glutamine formation. This is evidence that fluorocitrate is a selective inhibitor of the glial Krebs' cycle. [14C]Citrate and 2-oxoglutarate labelled amino acids in a manner similar to [14C]acetate, which shows that these substrates are taken up and metabolized by glial cells. Differences in the labelling of gamma-aminobutyric acid (GABA) from [14C]acetate and citrate suggest that astrocytes associated with GABAergic and glutamatergic nerve terminals may differ in their preference for amino acid precursors. |
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Authors:
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B Hassel; R E Paulsen; A Johnsen; F Fonnum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 576 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-10-06 Completed Date: 1992-10-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 120-4 Citation Subset: IM |
Affiliation:
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Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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metabolism Animals Aspartic Acid / metabolism Carbon Radioisotopes Citrates / administration & dosage, metabolism, pharmacology* Corpus Striatum / drug effects, metabolism* Glutamates / metabolism Glutamine / metabolism Ketoglutaric Acids / metabolism Male Neuroglia / drug effects, metabolism* Radioisotope Dilution Technique Rats Rats, Inbred Strains Reference Values Stereotaxic Techniques gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Carbon Radioisotopes; 0/Citrates; 0/Glutamates; 0/Ketoglutaric Acids; 357-89-1/fluorocitrate; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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