Document Detail


Selective increase in somatostatin mRNA expression in human basal ganglia in Parkinson's disease.
MedLine Citation:
PMID:  9406918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of the neurotransmitter somatostatin (SS) have previously been shown to be reduced in the cortex and hippocampus of demented parkinsonian patients and patients with Alzheimer's disease. In situ hybridisation histochemistry (ISHH) was performed with an 35S tail-labelled oligonucleotide DNA probe to human SS mRNA, to examine its expression within the striatum, medial medullary lamina (MML) and reticular thalamic nucleus in Parkinson's disease (PD) and in matched controls. A chronic unilaterally MPTP-lesioned L-DOPA-naive primate model was also examined for comparison of SS mRNA expression with that in human L-DOPA treated PD subjects. Quantitation of SS mRNA expression on emulsion dipped sections revealed a significant increase (82%) in the MML of the globus pallidus in PD (56.5 microm2 of silver grain/cell, n = 9 cases) compared to controls (26.3 microm2/cell, n = 13 cases, p < 0.01, Student's t-test), paralleling the increase previously observed by this group for NOS mRNA. SS mRNA expression was higher in the dorsolateral than ventromedial putamen in controls (p < 0.001; DL: 24.89 +/- SEM 1.35; VM: 17.96 +/- SEM 2.63; n = 14) but this gradient was lost in PD cases (p > 0.05; DL: 22.68 +/- 1.94; VM: 22.17 +/- 2.94; n = 10). These findings suggest specific modification of basal ganglia SS-ergic pathways in PD.
Authors:
D J Eve; A P Nisbet; A E Kingsbury; J Temlett; C D Marsden; O J Foster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  50     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-70     Citation Subset:  IM    
Affiliation:
Parkinson's Disease Society Brain Research Centre (Brain Bank), London, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Basal Ganglia / metabolism*
Case-Control Studies
Female
Humans
Male
Middle Aged
Oligonucleotide Probes
Parkinson Disease / metabolism*
RNA, Messenger / biosynthesis*
Reproducibility of Results
Somatostatin / genetics*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Oligonucleotide Probes; 0/RNA, Messenger; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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