Document Detail

Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone.
MedLine Citation:
PMID:  2141379     Owner:  NLM     Status:  MEDLINE    
Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites.
S Q Luo; T Ransom; E T Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  46     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-23     Completed Date:  1990-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1643-8     Citation Subset:  IM    
Department of Nutritional Sciences, University of Toronto, Ontario, Canada.
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MeSH Terms
Analysis of Variance
Buspirone / pharmacology*
Dietary Carbohydrates / metabolism*
Dose-Response Relationship, Drug
Drug Interactions
Eating / drug effects
Fluoxetine / pharmacology
Food Preferences / drug effects*
Naphthalenes / pharmacology*
Rats, Inbred Strains
Tetrahydronaphthalenes / pharmacology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Naphthalenes; 0/Tetrahydronaphthalenes; 36505-84-7/Buspirone; 54910-89-3/Fluoxetine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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