Document Detail


Selective inactivity of TGF-beta/decorin complexes.
MedLine Citation:
PMID:  7957866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies had shown that binding of TGF-beta to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF-beta 1-mediated up-regulation of biglycan synthesis. However, the down-regulation of proteoglycan-100 remained unaltered. Even in the presence of a 100,000-fold molar excess of decorin, TGF-beta 1 was fully active in U937 monocytes with respect to the inhibition of cell proliferation. There was no inhibition of the TGF-beta-mediated stimulation of the retraction of fibroblast-populated collagen lattices. Thus, the formation of TGF-beta/decorin complexes leads to the neutralization of distinct effects only.
Authors:
H Hausser; A Gröning; A Hasilik; E Schönherr; H Kresse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  353     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-29     Completed Date:  1994-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  243-5     Citation Subset:  IM    
Affiliation:
Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Germany.
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MeSH Terms
Descriptor/Qualifier:
Cell Division / drug effects
Collagen
Down-Regulation / drug effects,  physiology
Extracellular Matrix Proteins
Humans
Monocytes / cytology,  metabolism
Osteosarcoma / metabolism
Proteoglycans / biosynthesis,  metabolism*,  pharmacology
Transforming Growth Factor beta / metabolism*,  pharmacology
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Proteoglycans; 0/Transforming Growth Factor beta; 0/decorin; 123939-84-4/biglycan; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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