Document Detail

Selective impairments in managerial knowledge following pre-frontal cortex damage.
MedLine Citation:
PMID:  7555008     Owner:  NLM     Status:  MEDLINE    
Script generation was investigated in patients with lesions in the prefrontal (n = 9) and posterior (n = 8) cortical regions and in normal subjects (n = 16). Three different activities ranging in degree of familiarity were studied. Frontal patients did not differ from patients with posterior lesion and Normal subjects in the number of actions evoked, mean evocation time, or centrality. Impairments in script information processing were observed only in patients with prefrontal lesions, and for the three types of scripts. Specifically these patients made errors in ordering actions in the correct temporal sequence, failed to close scripts and to remain within the stated boundaries, and made deviant estimates of action importance. The results suggest that pre-frontal cortical lesions provoke a selective impairment in managerial knowledge (Grafman, 1989) that may contribute to difficulties in the formulation and execution of plans.
A Sirigu; T Zalla; B Pillon; J Grafman; Y Agid; B Dubois
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cortex; a journal devoted to the study of the nervous system and behavior     Volume:  31     ISSN:  0010-9452     ISO Abbreviation:  Cortex     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-22     Completed Date:  1995-11-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0100725     Medline TA:  Cortex     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  301-16     Citation Subset:  IM    
I.N.S.E.R.M. Unité 289, Hôpital de la Salpétrière, Paris, France.
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MeSH Terms
Brain Damage, Chronic / physiopathology*,  psychology*
Decision Making*
Middle Aged
Neural Pathways / physiopathology
Prefrontal Cortex / physiopathology*
Reaction Time
Task Performance and Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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