Document Detail

Selective impairment of fornix-transected rats on a new nonspatial, odor-guided task.
MedLine Citation:
PMID:  12625456     Owner:  NLM     Status:  MEDLINE    
In the present experiment, sham-operated (SH) and fornix-transected (FX) rats were trained on a new nonspatial, odor-guided task. On each session, eight odor pairs were presented twice. On the first occurrence of a pair, rats were reinforced for pushing the container (go response) in which the olfactory stimuli were placed. On the second occurrence, they were not reinforced and had to refrain from responding (no-go response) to be scored as success. Rats were first trained to criterion on odor pairs made of replicates of the same odor (S pairs). Then they were trained to criterion on pairs made of different odors, each member of the pair overlapping with that of another pair (O pairs) and finally, on pairs of different odors with no overlap (NO pairs). The results showed that the number of sessions to reach criterion was significantly higher in FX than in SH rats during training on O pairs, but not during training on S or on NO pairs. These findings are consistent with the configural (Rudy and Sutherland, 1995: Hippocampus 5:375-389) or relational (Eichenbaum et al., 1994: Behav Brain Sci 17:449-518) account of the hippocampal memory function.
C Hudon; F Y Doré; S Goulet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hippocampus     Volume:  13     ISSN:  1050-9631     ISO Abbreviation:  Hippocampus     Publication Date:  2003  
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  48-52     Citation Subset:  IM    
Ecole de Psychologie, Université Laval, Québec, Canada.
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MeSH Terms
Fornix, Brain / injuries*,  physiopathology,  surgery
Hippocampus / physiopathology*
Learning / physiology
Learning Disorders / etiology,  pathology,  physiopathology*
Memory / physiology
Memory Disorders / etiology,  pathology,  physiopathology*
Models, Neurological
Olfactory Pathways / physiology*
Psychomotor Performance / physiology
Rats, Long-Evans
Smell / physiology*

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