Document Detail

Selective immunoglobulin M deficiency in an adult with Streptococcus pneumoniae sepsis and invasive aspergillosis.
MedLine Citation:
PMID:  18564634     Owner:  NLM     Status:  MEDLINE    
Primary selective immunoglobulin (Ig) M deficiency usually presents early in life with recurrent or severe infections caused by encapsulated and gram-negative organisms. Primary selective IgM deficiency in adults is rare and is usually associated with autoimmune diseases or malignant neoplasm. We performed an extensive immunological analysis of innate and adaptive immunity in an adult patient with possible primary selective IgM deficiency who presented with life-threatening Streptococcus pneumoniae septic shock and invasive Aspergillus fumigatus infection. The patient had no evidence of autoimmune disease or malignant neoplasm. Serum IgG, IgA, and IgE were normal; however, serum IgM levels and specific antibody titers against all 14 pneumococcal polysaccharide serotypes were consistently low. Complement CH50, C3, C4, and neutrophil phagocytosis and oxidative burst were normal. Toll-like receptor expression on monocytes was also normal. Therefore, adult patients with serious life-threatening and unusual infections should be investigated for possible selective primary IgM deficiency.
R Hong; S Gupta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  18     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-10-06     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  214-8     Citation Subset:  IM    
Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA.
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MeSH Terms
Aspergillosis / etiology,  immunology*
Aspergillus fumigatus* / immunology
Dysgammaglobulinemia / complications,  immunology*
Immunity, Active
Immunity, Innate
Immunoglobulin M / deficiency*
Middle Aged
Pneumococcal Infections / etiology,  immunology*,  microbiology
Shock, Septic / etiology,  immunology
Streptococcus pneumoniae / immunology
Reg. No./Substance:
0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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