Document Detail

Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: a brain SPECT finding by statistical parametric mapping.
MedLine Citation:
PMID:  14512719     Owner:  NLM     Status:  MEDLINE    
This study tests the hypothesis that depression in patients with Alzheimer's disease (AD) is due to a specific pathogenesis rather than a reactive phenomenon. Forty-three AD patients received a psychiatrist's interview, neuropsychological assessments, and a 99mTc-hexamethyl propyleneamine oxime single photon emission computed tomography (HMPAO-SPECT). Analysis by statistical parametric mapping (SPM) showed that the depressed group had selective hypoperfusion in the bilateral anterior and posterior cingulate gyri and precuneus. Using the Hamilton Depression Rating Scale as a parameter, an inverse correlation was found between cerebral perfusion and the severity of depression. The right anterior cingulate gyrus demonstrated a most significant reduction in perfusion. These locations are akin to the imaging findings in patients with primary depression, indicating a specific pathogenesis for depression in AD.
Yi-Chu Liao; Ren-Shyan Liu; Yi-Chung Lee; Chen-Ming Sun; Chia-Yih Liu; Po-Shan Wang; Pei-Ning Wang; Hsiu-Chih Liu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  16     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-26     Completed Date:  2003-11-06     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  238-44     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
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MeSH Terms
Alzheimer Disease / complications,  physiopathology,  radionuclide imaging*
Brain Mapping / methods*
Depressive Disorder / complications,  physiopathology,  radionuclide imaging*
Gyrus Cinguli / blood supply*,  radionuclide imaging
Neuropsychological Tests
Psychiatric Status Rating Scales
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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