Document Detail

Selective histamine blockade in childhood asthma; the effect of terfenadine on resting bronchial tone and exercise induced bronchoconstriction.
MedLine Citation:
PMID:  2573918     Owner:  NLM     Status:  MEDLINE    
The orally active histamine H1 blocker terfenadine was investigated for its effect on resting bronchial tone and exercise induced bronchoconstriction in 20 asthmatic children by a double blind placebo controlled study. Terfenadine produced acute broncholidation with an average 32% improvement in FEV1 by 3 h. After exercise challenge terfenadine partially inhibited exercise induced bronchoconstriction. The maximum fall in PEFR after exercise was reduced from 32% after placebo to 21.5% after terfenadine. These results suggest that asthmatic children have background resting 'histamine tone' that is reversible by histamine H1 blockage.
P I MacFarlane; D P Heaf
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Respiratory medicine     Volume:  83     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1990-01-05     Completed Date:  1990-01-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Respiratory Unit, Royal Liverpool Children's Hospital, Alder Hey, U.K.
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MeSH Terms
Airway Resistance / drug effects
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy
Benzhydryl Compounds / therapeutic use*
Bronchi / drug effects
Child, Preschool
Clinical Trials as Topic
Double-Blind Method
Forced Expiratory Volume / drug effects
Histamine H1 Antagonists / therapeutic use*
Peak Expiratory Flow Rate / drug effects
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Histamine H1 Antagonists; 50679-08-8/Terfenadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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