Document Detail


Selective hippocampal damage in rhesus monkeys impairs spatial memory in an open-field test.
MedLine Citation:
PMID:  15382251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hippocampus is critical for remembering locations in a wide variety of species, including humans. However, recent findings from monkeys following selective hippocampal lesions have been equivocal. To approximate more closely the situations in which rodents and birds are tested, we used a spatial memory task in which rhesus monkeys (Macaca mulatta) moved about freely in a large room, on a tether. We used MRI-guided stereotaxic surgery to produce selective hippocampal lesions in five monkeys, and retained five unoperated control monkeys. In the study phase of each trial of the matching-to-location task, monkeys found food in one site in an array of identical foraging sites. During the test, which occurred after a delay, monkeys could return to the site where the food had been found during study to obtain more food. In Experiment 1, normal monkeys showed a small significant tendency to return directly to a site where they had previously found food that day. Operated monkeys showed no such matching tendency. In Experiment 2, further training produced reliable matching-to-location performance in both groups at short delays, but monkeys with selective hippocampal lesions rapidly forgot the location of the food. In Experiment 3, we tested whether monkeys used a "cognitive map" to encode the location of the hidden food, by requiring them to relocate the food from a starting location different from that used during study. As a group, monkeys were more accurate than expected by chance, indicating that they did encode the rewarded location with respect to allocentric landmarks; however, both groups of monkeys were significantly worse at relocating the food when required to approach from a different location. In Experiment 4, probe trials using symmetrical test arrays found no evidence for egocentric coding of the rewarded location.
Authors:
Robert R Hampton; Benjamin M Hampstead; Elisabeth A Murray
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hippocampus     Volume:  14     ISSN:  1050-9631     ISO Abbreviation:  Hippocampus     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-21     Completed Date:  2005-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  808-18     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Affiliation:
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA. robert@ln.nimh.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cues
Female
Hippocampus / injuries*
Macaca mulatta
Magnetic Resonance Imaging
Male
Memory / physiology*
Psychomotor Performance / physiology
Space Perception / physiology*
Stereotaxic Techniques

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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