Document Detail


Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect.
MedLine Citation:
PMID:  23359250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: A primary defect in mitochondrial fatty acid β-oxidation causes hepatic insulin resistance selective to hepatic glycogen metabolism that is associated with elevated methylated PP2A-C, but independent of other mechanisms commonly considered responsible for insulin resistance. (HEPATOLOGY 2013;).
Authors:
R Scott Rector; E Matthew Morris; Suzanne Ridenhour; Grace M Meers; Fong-Fu Hsu; John Turk; Jamal A Ibdah
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-04-26
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-08-29    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2213-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Fatty Acids / metabolism
Fatty Liver / genetics,  metabolism*
Glucose Clamp Technique
Heterozygote
Insulin / metabolism
Insulin Resistance*
Lipid Metabolism*
Male
Mice
Mitochondria / metabolism
Mitochondrial Trifunctional Protein
Multienzyme Complexes / genetics*
Oxidation-Reduction
Grant Support
ID/Acronym/Agency:
DK-56345/DK/NIDDK NIH HHS; F32 DK-83182/DK/NIDDK NIH HHS; F32 DK083182/DK/NIDDK NIH HHS; P30 DK020579/DK/NIDDK NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P30-DK56341/DK/NIDDK NIH HHS; P41 RR000954/RR/NCRR NIH HHS; P41-RR00954/RR/NCRR NIH HHS; P60 DK020579/DK/NIDDK NIH HHS; P60-DK20579/DK/NIDDK NIH HHS; R01 DK056345/DK/NIDDK NIH HHS; T32 AR 048523-07/AR/NIAMS NIH HHS; T32 AR048523/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Insulin; 0/Multienzyme Complexes; EC 2.3.1.16/Mitochondrial Trifunctional Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterizing crystal disorder of trospium chloride: A comprehensive,(13) C CP/MAS NMR, DSC, FTIR, ...
Next Document:  Turkish adaptation of the short form of the pelvic organ Prolapse/Urinary Incontinence Sexual Functi...