| Selective fluoroalkylations with fluorinated sulfones, sulfoxides, and sulfides. | |
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MedLine Citation:
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PMID: 17708659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Efficient fluoroalkylations have been proven to be a highly useful strategy for the synthesis of bioactive fluorine-containing compounds and other materials. The design and use of a single category of reagents for multiple synthetic goals are much more attractive to preparative organic chemists. In this Account, we show how we have succeeded in the nucleophilic trifluoromethylation, difluoromethylation, difluoromethylenation, (phenylsulfonyl)difluoromethylation, (phenylthio)difluoromethylation, and monofluoromethylation as well as radical (phenylsulfonyl)difluoromethylation and electrophilic difluoromethylation by using fluorinated sulfones, sulfoxides, sulfides, or fluorinated sulfonium salts. The chemistry not only provides practically powerful synthetic methods, but the molecular design concept that we have developed may also be adopted to tackle other related chemical problems. |
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Authors:
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G K Surya Prakash; Jinbo Hu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-08-21 |
Journal Detail:
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Title: Accounts of chemical research Volume: 40 ISSN: 0001-4842 ISO Abbreviation: Acc. Chem. Res. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-17 Completed Date: 2007-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0157313 Medline TA: Acc Chem Res Country: United States |
Other Details:
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Languages: eng Pagination: 921-30 Citation Subset: IM |
Affiliation:
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Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylation Fluorine / chemistry* Indicators and Reagents / chemistry Sulfides / chemistry* Sulfones / chemistry* Sulfoxides / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Sulfides; 0/Sulfones; 0/Sulfoxides; 7782-41-4/Fluorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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