| Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex. | |
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MedLine Citation:
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PMID: 8692994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Visual information in primates is relayed from the dorsal lateral geniculate nucleus to the cerebral cortex by three parallel neuronal channels designated the parvocellular, magnocellular, and interlaminar pathways. Here we report that m2 muscarinic acetylcholine receptor in the macaque monkey visual cortex is selectively associated with synaptic circuits subserving the function of only one of these channels. The m2 receptor protein is enriched both in layer IV axons originating from parvocellular layers of the dorsal lateral geniculate nucleus and in cytochrome oxidase poor interblob compartments in layers II and III, which are linked with the parvocellular pathway. In these compartments, m2 receptors appear to be heteroreceptors, i.e., they are associated predominantly with asymmetric, noncholinergic synapses, suggesting a selective role in the modulation of excitatory neurotransmission through the parvocellular visual channel. |
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Authors:
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L Mrzljak; A I Levey; P Rakic |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 93 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-29 Completed Date: 1996-08-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7337-40 Citation Subset: IM |
Affiliation:
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Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06511, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism, ultrastructure Dendrites / metabolism, ultrastructure Immunohistochemistry Macaca mulatta Microscopy, Immunoelectron Neurons / cytology, metabolism*, ultrastructure Receptor, Muscarinic M2 Receptors, Muscarinic / analysis, biosynthesis* Synapses / metabolism*, ultrastructure Visual Cortex / cytology, metabolism*, ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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EY 02593/EY/NEI NIH HHS; MH 44866/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Muscarinic M2; 0/Receptors, Muscarinic |
| Comments/Corrections | |
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