Document Detail

Selective expression of cell type specific cell-cell adhesion molecules in mouse hybrid cells.
MedLine Citation:
PMID:  6884616     Owner:  NLM     Status:  MEDLINE    
Ca2+-dependent cell-cell adhesion systems (CDS) are present in a variety of cells which can be grouped into at least two qualitatively different types, the teratocarcinoma type (t-CDS) and the fibroblast type (f-CDS), where different classes of adhesion molecules operate, respectively. In order to study the regulatory mechanisms of expression of different CDS types, we made cell hybrids between teratocarcinoma OTF9 cells (t-CDS) and fibroblast L cells (f-CDS), and between OTF9 cells (t-CDS) and hepatoma MH cells (no CDS). We thus examined which type of CDS is expressed in hybrid clones using a probe, an antibody that recognizes t-CDS selectively. We isolated many hybrid clones with different phenotypes, all displaying CDS activity, and found that CDS functioning in each clone was either t-CDS or another type(s) of CDS. There were no clones in which both t-CDS and another type(s) of CDS are active. We therefore suggested that the expression or function of t-CDS and other types of CDS is mutually exclusive within a single cell.
T Atsumi; M Takeichi; T S Okada
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  24     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / metabolism
Antigens / analysis*
Calcium / pharmacology*
Cell Adhesion*
Cell Adhesion Molecules
Cell Aggregation
Cell Line
Hybrid Cells
L Cells (Cell Line)
Liver Neoplasms, Experimental
Reg. No./Substance:
0/Antigens; 0/Cell Adhesion Molecules; 7440-70-2/Calcium; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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