| Selective estrogen receptor modulator medicinal chemistry at Merck. A review. | |
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MedLine Citation:
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PMID: 18537689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selective estrogen receptor modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-alpha selective antagonists and ER-beta agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008. |
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Authors:
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T A Blizzard |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current topics in medicinal chemistry Volume: 8 ISSN: 1873-4294 ISO Abbreviation: Curr Top Med Chem Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-09 Completed Date: 2008-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 792-812 Citation Subset: IM |
Affiliation:
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Merck Research Laboratories, RY800-B116 P.O. Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical Humans Ligands Selective Estrogen Receptor Modulators / chemistry*, pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Selective Estrogen Receptor Modulators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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