Document Detail

Selective embolization of thyroid arteries as a preresective and palliative treatment of thyroid cancer.
MedLine Citation:
PMID:  17914113     Owner:  NLM     Status:  MEDLINE    
Although many tumours of head and neck have been successfully embolized, the number of publications on the application of selective embolization of thyroid arteries (SETA) is limited. The aim of the present study is to evaluate the safety, efficacy and possible indications and contraindications for preresective or palliative SETA in thyroid cancer. The study group comprised 20 patients with thyroid tumours: 7 cases of advanced inoperable anaplastic thyroid cancer (ATC) and 13 cases of differentiated thyroid carcinoma (DTC). All the patients underwent SETA of the superior and/or inferior thyroid arteries. After SETA, selective angiographies of thyroid arteries were performed to ensure that the targeted arteries had been completely occluded. In all the cases, SETA decreased the blood flow through the thyroid. Preresective SETA limited bleeding during surgery and decreased operating time. We observed a massive increase of thyroglobulin (Tg) concentrations in cases of DTC that started 36-48 h after SETA and did not occur in cases of ATC. Although SETA had no influence on the mortality of ATC patients, they reported improvements in swallowing, breathing and decrease of the pain. Concluding, SETA is minimally invasive and safe method limiting blood flow through thyroid tumours. In DTC patients, SETA causes ischaemic necrosis of the gland which results in important increases in serum concentrations of Tg. Therefore, thyroidectomy should be performed during the first 36 h after preresective embolization. Moreover, SETA may become an attractive option of palliative treatment for ATC patients with intractable bleeding, pain or signs of tracheal and oesophageal compression.
Marek Dedecjus; Jozef Tazbir; Zbigniew Kaurzel; Andrzej Lewinski; Grzegorz Strozyk; Jan Brzezinski
Related Documents :
23627243 - Treatment of canine pulmonary arterial hypertension: is tadalafil an appropriate altern...
7455113 - Ferromagnetic embolization. experimental evaluation.
17298773 - Stroke attributable to acute basilar occlusion.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine-related cancer     Volume:  14     ISSN:  1351-0088     ISO Abbreviation:  Endocr. Relat. Cancer     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436481     Medline TA:  Endocr Relat Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
Department of General and Endocrine Surgery, Medical University of Lodz, Lodz, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Carcinoma / diagnosis,  therapy*
Combined Modality Therapy
Embolization, Therapeutic / adverse effects,  methods*
Middle Aged
Neoadjuvant Therapy / methods*
Palliative Care / methods*
Thyroid Gland / blood supply*
Thyroid Neoplasms / diagnosis,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroi...
Next Document:  Gastrointestinal stromal tumors regularly express synaptic vesicle proteins: evidence of a neuroendo...