Document Detail


Selective elimination of chromosomally unbalanced zygotes at the two-cell stage in the Chinese hamster.
MedLine Citation:
PMID:  6705565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gametic and zygotic selection of genome imbalance was investigated in the Chinese hamster by direct chromosome analyses of spermatocytes and preimplantation embryos from crosses between chromosomally normal females and males heterozygous for a reciprocal translocation, T(2;10)3Idr, abbreviated here as T3. The karyotypes and the frequencies of embryos observed at the first cleavage in the cross +/+female X T3/+male were consistent with those expected from MII scoring in male T3 heterozygotes. Therefore, it was concluded that there was neither gametic selection against genome imbalance nor zygotic selection from fertilization until the first cleavage metaphase. However, 9.1-10.8% of embryos were arrested at the two-cell stage, and karyotypes of these embryos were confirmed as 22(2,10,10,10(2)), 21(2,10,10), and 21(2,10,10(2)). The common abnormality of these embryos was partial monosomy of chromosome 2. Among day 4 embryos, some chromosomally unbalanced embryos, mainly with a deficiency of other segments of chromosomes 2 and 10, had fewer blastomeres than chromosomally balanced embryos. This finding suggests that cleavage of these embryos had been retarded by day 4 of gestation.
Authors:
S Sonta; K Fukui; H Yamamura
Related Documents :
1766925 - Chromosome analysis of multipronuclear human oocytes after in vitro fertilization.
10098475 - Chromosome abnormalities in human embryos.
7878225 - Hprt activity in embryos of a south american opossum monodelphis domestica.
9041135 - In vivo aging of oocytes influences the behavior of nuclei transferred to enucleated ra...
9778525 - Chromosome arrangement within a bacterium.
15262185 - Interactions between common genetic polymorphisms in abcg5/g8 and cyp7a1 on ldl cholest...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  38     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1984  
Date Detail:
Created Date:  1984-05-23     Completed Date:  1984-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / physiology*
Chromosome Banding
Chromosomes / physiology*
Cricetinae
Cricetulus
Female
Heterozygote
Karyotyping
Male
Metaphase
Spermatocytes / physiology*
Spermatozoa / physiology*
Translocation, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Induction of sister chromatid exchange by 3-aminobenzamide is independent of bromodeoxyuridine.
Next Document:  Inhibitory effect of ethidium bromide on mitotic chromosome condensation and its application to high...