Document Detail


Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion.
MedLine Citation:
PMID:  6112710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weight but with similar activity have been noted. Recently two such peptides have been characterized as the 28-amino acid SRIF-28 (from porcine gastro-intestinal tract and porcine and ovine hypothalamus and the 25-amino acid SRIF-25 (from ovine hypothalamus), each of which consists of an N-terminal extension of SRIF-14. We now report that SRIF-28 and SRIF-25 are more potent than SRIF-14 in the inhibition of insulin release, but that SRIF-14 preferentially inhibits glucagon release. This suggests that SRIF-28 and SRIF-25 are not mere biosynthetic precursors of SRIF-14 and that their differential release may be physiologically important.
Authors:
L Mandarino; D Stenner; W Blanchard; S Nissen; J Gerich; N Ling; P Brazeau; P Bohlen; F Esch; R Guillemin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  291     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-23     Completed Date:  1981-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  76-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / antagonists & inhibitors
Glucagon / secretion*
Insulin / secretion*
Islets of Langerhans / secretion*
Protein Precursors / pharmacology*
Rats
Secretory Rate / drug effects
Somatostatin / pharmacology*
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
AM07147/AM/NIADDK NIH HHS; AM07352/AM/NIADDK NIH HHS; AM20837/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Protein Precursors; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 74-79-3/Arginine; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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