| Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion. | |
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MedLine Citation:
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PMID: 6112710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weight but with similar activity have been noted. Recently two such peptides have been characterized as the 28-amino acid SRIF-28 (from porcine gastro-intestinal tract and porcine and ovine hypothalamus and the 25-amino acid SRIF-25 (from ovine hypothalamus), each of which consists of an N-terminal extension of SRIF-14. We now report that SRIF-28 and SRIF-25 are more potent than SRIF-14 in the inhibition of insulin release, but that SRIF-14 preferentially inhibits glucagon release. This suggests that SRIF-28 and SRIF-25 are not mere biosynthetic precursors of SRIF-14 and that their differential release may be physiologically important. |
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Authors:
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L Mandarino; D Stenner; W Blanchard; S Nissen; J Gerich; N Ling; P Brazeau; P Bohlen; F Esch; R Guillemin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature Volume: 291 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-07-23 Completed Date: 1981-07-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 76-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / antagonists & inhibitors Glucagon / secretion* Insulin / secretion* Islets of Langerhans / secretion* Protein Precursors / pharmacology* Rats Secretory Rate / drug effects Somatostatin / pharmacology* Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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AM07147/AM/NIADDK NIH HHS; AM07352/AM/NIADDK NIH HHS; AM20837/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protein Precursors; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 74-79-3/Arginine; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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