| Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine production. | |
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MedLine Citation:
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PMID: 20456417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modulation of host immunity is an important potential mechanism by which probiotics confer health benefits. This study was designed to investigate the effects of a probiotic strain, Lactobacillus casei Shirota (LcS), on immune function using human peripheral blood mononuclear cells (PBMC) in vitro. In addition, the role of monocytes in LcS-induced immunity was also explored. LcS promoted natural killer (NK) cell activity and preferentially induced expression of CD69 and CD25 on CD8(+) and CD56(+) subsets in the absence of any other stimulus. LcS also induced production of interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF)-alpha, IL-12 and IL-10 in the absence of lipopolysaccharide (LPS). In the presence of LPS, LcS enhanced IL-1beta production but inhibited LPS-induced IL-10 and IL-6 production, and had no further effect on TNF-alpha and IL-12 production. Monocyte depletion reduced significantly the impact of LcS on lymphocyte activation, cytokine production and natural killer (NK) cell activity. In conclusion, LcS activated cytotoxic lymphocytes preferentially in both the innate and specific immune systems, which suggests that LcS could potentiate the destruction of infected cells in the body. LcS also induced both proinflammatory and anti-inflammatory cytokine production in the absence of LPS, but in some cases inhibited LPS-induced cytokine production. Monocytes play an important role in LcS-induced immunological responses. |
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Authors:
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H Dong; I Rowland; K M Tuohy; L V Thomas; P Yaqoob |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-07 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 161 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-08-27 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 378-88 Citation Subset: IM |
Affiliation:
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Department of Food and Nutritional Sciences, University of Reading, Reading, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / metabolism Antigens, Differentiation, T-Lymphocyte / metabolism Blood / drug effects, immunology, metabolism CD4-Positive T-Lymphocytes / drug effects, immunology, metabolism CD8-Positive T-Lymphocytes / drug effects, immunology, metabolism Cell Separation Cells, Cultured Concanavalin A / pharmacology Cytokines / metabolism* Cytotoxicity, Immunologic / immunology Humans Interleukin-2 Receptor alpha Subunit / metabolism Interleukins / metabolism Killer Cells, Natural / immunology* Lactobacillus casei / immunology* Lectins, C-Type / metabolism Leukocytes, Mononuclear / cytology, drug effects, immunology, metabolism Lipopolysaccharides / pharmacology Lymphocyte Activation / drug effects, immunology* Monocytes / cytology, immunology, metabolism Probiotics* T-Lymphocytes / drug effects, immunology*, metabolism Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, T-Lymphocyte; 0/CD69 antigen; 0/Cytokines; 0/IL2RA protein, human; 0/Interleukin-2 Receptor alpha Subunit; 0/Interleukins; 0/Lectins, C-Type; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 11028-71-0/Concanavalin A |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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