Document Detail


Selective direct toxicity of cocaine on fetal mouse neurons. Teratogenic implications of neurite and apoptotic neuronal loss.
MedLine Citation:
PMID:  9668397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This chapter reviews epidemiologic clinical surveys and experimental animal studies, indicating that cocaine may induce severe teratogenic effects on the developing brain. Evidence for direct toxic effects is next presented. Using cocultures of embryonic brain cells, we demonstrate that cocaine selectively affects neuronal cells, first causing a dramatic reduction in the number and length of neurites, then extensive neuronal death by apoptosis. By contrast, cocaine affected neither the abundance of astroglial cells nor their glial fibrillary acidic protein content. These effects are not due to cocaine metabolites. The contributions of indirect and direct effects that could account for cocaine neuroteratogenicity are finally discussed.
Authors:
M C Nassogne; P Evrard; P J Courtoy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  846     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-31     Completed Date:  1998-07-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-68     Citation Subset:  IM    
Affiliation:
Cell Biology Unit, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium. Nassogne@cell.ucl.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Brain / abnormalities,  drug effects*,  pathology
Cocaine / toxicity*
Female
Fetal Growth Retardation
Fetus
Humans
Infant, Low Birth Weight
Infant, Newborn
Mice
Neurites / drug effects*,  physiology
Neurons / drug effects*,  pathology,  physiology
Pregnancy
Prenatal Exposure Delayed Effects
Substance-Related Disorders
Teratogens*
Chemical
Reg. No./Substance:
0/Teratogens; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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